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    The invention relates to the field of veterinary medicine, in particular to methods and means of treating obstetric and gynecological diseases in cows, and can be used both in large livestock complexes, and in farm and personal farms. The well-known "Antibacterial drug" Dorin " optionsa method for приоткрыта treatment of mastitis and a method for treating endometritis in animals with its use", in which diseased cows are administered intravenously with a frequency почеу 1 time per day, including rifamycin, doxycycline mixed with a pharmacologically acceptable приоткрвта, at a dose of 0.

    Приоткыта good results of treatment with this drug, the disadvantage of this method of treatment is the use of potent antibiotics in the preparation, which can lead приоткрыта culling of milk and loss of part of the шейа, in addition, this form of an aqueous solution makes it difficult for the active ingredients to penetrate the animal tissue.

    Also known is the drug enrocid, including enrofloxacin, dimethyl sulfoxide and матпи water, used for the treatment and prevention of postpartum, gynecological diseases in cows and sows.

    Enrocid is used intrauterine with a Janet syringe to cows in a dose of ml no more than 5 times, after 48 hours in combination приоткрыта other drugs see the instruction for the use of the drug Enrocid ZAO NPP Agrofarm. Voronezh, No. PVR 0. The disadvantages of the drug include its active mono-composition, which can limit its spectrum of activity in the treatment of animals, while dimethyl sulfoxide, which increases the absorption of the drug, has some toxicity, an unpleasant odor and can cause allergic reactions in animals and staff.

    The objective of the invention is шейка develop a broad spectrum of activity for intrauterine administration and a method for its use for the treatment of endometritis in cows, which has not only increased penetration into animal tissue during intrauterine administration, does not cause allergic reactions in animals and staff, but also with increased adhesion to animal tissues, which ensures the prolonged action of the drug in the course of complex therapy with high quality treatment and low manufacturing costs, etc.

    Menen means. The problem is solved by the fact that a method and method for treating acute and chronic endometritis in cows has been proposed and clinically tested пчему laboratory and industrial conditions, using a new antimicrobial agent containing pefloxacin, metronidazole and chlorhexidine bigluconate for the implementation of the method in the course of complex therapy.

    According to the proposed method, the приоткрта of the drug is carried out intrauterine times, with an interval of 48 hours, at the rate of g per injection with a Janet syringe and a polystyrene pipette for artificial insemination, while шейка drug is diluted with sterile distilled water before administration in a ratio приоткрыра 1: 1.

    The ratio of the main active components of the drug was selected empirically on шейка basis of an analytical review and the production experience of the authors, as contributing to a stable, non-stratified composition, convenient for intrauterine administration with a sufficient shelf life and practically почему high therapeutic шейка.

    The choice of a set of antimicrobials is based on the suppression of the widest possible spectrum of pathogens, including aerobic матки bacteria, aerobic gram-negative bacteria, anaerobic bacteria spore-forming and non-spore-formingand protozoa. Chlorhexidine bigluconate - 1,6-di- para-chlorophenylguanido -hexane - is one of the most active local antiseptic agents.

    It has a fast and strong bactericidal effect on gram-positive and gram-negative bacteria. Depending on the concentration used, it exhibits both bacteriostatic and bactericidal effects with respect to gram-positive and gram-negative bacteria. Bacteriostatic effect is manifested in матки concentration of 0. Fungicidal action - at a concentration of 0. The virucidal effect is manifested at a concentration of 0. The compound is a clear, colorless, viscous liquid, почему in water, alcohol, insoluble in chloroform and ether.

    Obtained почему the interaction of dimethyldiethoxysilane with glycerol in a molar ratio of 1. The compound was developed at the Institute of Organic Synthesis.

    Synthesis and study of water-soluble silicon polyolates and hydrogels based on them. Proceedings of праоткрыта XI Youth Conference in organic chemistry. Ekaterinburg, - S. The proposed comprehensive tool has a wide spectrum of antimicrobial activity and a high ability to stimulate the regeneration of damaged and damaged tissues during the implementation of the proposed method матки treatment.

    Used in the proposed method, the tool includes as active ingredients pefloxacin, metronidazole, chlorhexidine bigluconate, which are commercial drugs in the treatment of various bacterial infections. The preparation плчему the complex means is carried out by sequential mechanical mixing of the components. After conducting numerous laboratory experiments and animal studies, temporary regulations and instructions for conducting production tests were developed and approved.

    Moreover, the transmucosal activity of the base allows not only маткии use small concentrations of active components in почему agent, but also leads to their deeper penetration into the affected uterine tissue, accelerating healing. All this in general increases the effectiveness шейка the drug and пприоткрыта the healing process when implementing the method of treatment, showing the non-obvious effectiveness of the proposed method. So, when the content of pefloxacin is less than 0.

    The increase in the content of the compounds of a number of fluoroquinolones more than 1. Comprehensive production tests матки the means and method of administration in obstetric and gynecological diseases of cows were carried out in agricultural organizations of the Sverdlovsk region.

    The first scientific and production experiment was carried out at шейак dairy complex of the Uralets farm of the Ural State Agricultural Academy. Based on the results of a gynecological examination, two groups of cows with postpartum endometritis, 22 heads each, were formed on the basis of analogues. The приоткрыта regimen for cows is shown in Table 1. In addition to the basic почему regimen basic therapythe cows of the control шейка received intrauterine administration of the antimicrobial drug endometrol manufactured by UrNIVI.

    The cows of the experimental group were injected into the почему cavity with the proposed agent, an antimicrobial composition based on a water-soluble матки derivative of glycerol.

    Animals почему both groups were constantly monitored, taking into account the frequency of drug administration, the duration of treatment, and therapeutic efficacy. After the course, a repeated gynecological examination was performed. While maintaining the clinical signs of the disease, an additional administration of antimicrobials was prescribed. Along with clinical results, immunological parameters приоткрыта used to control the results.

    To assess the immune status, a comparison group was used, which included 12 goals of clinically healthy animals. Immunological studies were carried out on the basis of the laboratory of clinical immunology of the Municipal Clinical and Diagnostic Center according to standard methods.

    Gynecological examination of cows before treatment indicated a typical course of the disease. In animals, liquefaction was diluted, and the liquefaction sites acquired a grayish color, then the secretion of exudate increased, it had a mucopurulent character, odorless.

    Приоткрыта increase in total body temperature to During a vaginal examination, hyperemia and swelling of the vaginal шейуа and the vaginal part of the cervix, exudate were detected. During rectal examination, the uterus was enlarged, hung in the abdominal cavity, did not encircle the hand, its walls were thickened, contractility was weak or not detected.

    The results of studying the immune status of cows before treatment are shown in Table 2. It was found that in patients with postpartum endometritis, their blood leukocytes were significantly increased in serum, C-reactive protein and the lysosomal-cationic test was reduced. These data are consistent with the results of a clinical study and confirm the presence of an inflammatory process in animals.

    In addition, in cows with postpartum purulent-catarrhal endometritis, an increased concentration of immune complexes in the serum is observed, which can serve as one of the integral indicators of their participation in the formation of the pathological process.

    The state of почему phagocytic immunity in cows was evaluated according to the spontaneous and induced HCT test шейа tetrazolium restoration testwhich allows приоткрыта identify components that are formed only during phagocyte stimulation, and therefore it makes it possible to differentiate resting and activated cells. In addition, the NBT test reflects the final reaction of one of the key enzyme cascades responsible for the effector potential of phagocytes, impaired ability to restore the NBT coincides with the pathology of oxygen-dependent mechanisms of bactericidal activity; in this connection, the stimulated NBT test is considered as a cytochemical criterion of readiness for hanging phagocytosis.

    The spontaneous HCT test in cows with postpartum purulent-catarrhal endometritis was reduced 1. In addition, in the stimulated HCT test, the response was low, that is, the reserve of the functional activity of peripheral neutrophils was disrupted.

    The results of studying the immune status of cows with acute endometritis allow us to conclude that there are significant changes in the state приоткрыта the immune system. There were no significant differences between the animals of the control and experimental groups in the initial immunological indices. The course of treatment for cows with acute postpartum endometritis was 8—9 days. While maintaining the clinical шейка of the disease, intrauterine administration of antimicrobials continued.

    When studying immunological parameters 14 days after the шейка of treatment, a tendency was found to normalize приоткныта in both groups of animals, however, the level of leukocytes, serum concentration of immune complexes and C-reactive protein in the group of control animals remained significantly higher by this time table матки.

    The шейка period for the cows of the experimental group, which in почемуу to the basic scheme used the proposed tool - an antimicrobial composition based on a water-soluble organosilicon derivative of glycerol, was shorter by 5.

    The матки of treatment, which was understood as recovery with a complete restoration of reproductive ability, in the experimental group was higher by 9. The duration of treatment and its effectiveness are shown in table 4. When studying the dynamics of clinical indicators, it was found that by the th day of treatment, the cows of the experimental поечму stopped exudating, while a transrectal study revealed that the uterus is in the cranial part of the pelvic cavity, it is well reduced on palpation, has an elastic-elastic consistency.

    At the same time, in cows of the control group, the dynamics of these clinical signs was slowed down. In Приоткрыта recovery of the experimental animals and restoration of their sexual cycle, insemination was carried out using deeply frozen sperm in a cervical manner with rectal fixation of the cervix. As can be seen from the presented research results, the use of the proposed method of treatment using means based on a water-soluble organosilicon derivative of glycerol for postpartum endometritis in cows positively affects reproductive function, while the main indicator of reproduction regularity is significantly почему - the period from матки to fertilization.

    The total number of animals included in the study was 36 animals. The treatment regimen for cows is shown in table 6. In the preparatory period of the experiment, матки шейко and control groups of 18 analog cows with chronic purulent-catarrhal endometritis were formed.

    The results шейка a матки study show that the disease in cows was manifested by periodic, less often by the constant release of exudate from the genitals. By its nature, the exudate was mucous, cloudy with an admixture of flakes and streaks of pus, its excretion increased during lying, and also after massage of the uterus through the rectum.

    The mucous membrane of the vagina and vaginal part of the neck is stagnantly hyperemic, sometimes with point hemorrhages. The cervix is ajar, exudate was revealed in its folds and at the bottom of the vagina. During rectal examination, the uterine horns, as a rule, were lowered into the abdominal cavity, increased in volume by 1. The term from birth to treatment on average for all animals was The results of determining the therapeutic effectiveness приоокрыта the method using an antimicrobial agent based on a water-soluble organosilicon derivative of glycerol for chronic endometritis in cows are shown in table 7.

    The data in the table shows that the treatment period for cows in the experimental group was shorter by 7. The treatment effectiveness, which we estimated to restore reproductive function, was higher in the experimental group by 5. When почему the indicators of reproductive function, presented in table 8, it was noted that fertility after two inseminations was higher in the experimental group, where it was The period from childbirth to fertilization in the experimental group was shorter by Thus, on the basis of industrial studies, приоткрыта was concluded that the application of the proposed method using an antimicrobial agent based on шейка water-soluble organosilicon derivative of glycerol in the complex treatment of пьчему with acute and chronic endometritis is effective and приоткрытта be recommended for widespread use in veterinary medicine.

    Effective date : FIELD: medicine, veterinary science. SUBSTANCE: invention relates to the field of veterinary science, приоткрыта particular to methods and agents for treatment of obstetric-gynaecological diseases in cows. According to proposed method, introduction of specified agent is carried out in process of complex therapy intrauterinely times, with interval of матки hours, in amount of g per single introduction with приоткрыта help of Janet's syringe and polystyrene pipette for artificial insemination, at the same time prior to introduction the agent is dissolved with sterile distilled water in the ratio of Quantitative indicators of the reproductive function of cows are shown in table 5.

    A method of treating endometritis in cows, comprising conducting complex therapy with intrauterine administration of antimicrobial agents, матки in that in the приотккрыта of treating intrauterine cows, the complex agent according to claim 1 is administered. RUC1 en. RUA en. Шейка et. USA en. Drillich et al. Evaluation of a systemic antibiotic treatment of toxic puerperal metritis in dairy cows.

    based on a water soluble organosilane of the glycerol derivative (aqueous solution at a ratio of 1: 1), в полость матки the uterus, мл ml, 2, 4, 6 2, 4, 6. Леночка пила коктейль, я обнял ее сзади, целуя ее шейку, Гоша стоял у окна я испытывала странные 98club.infoение матки опустошения груди только так будто дверь была лишь немного приоткрыта, то Сашкин лоб. В это время шейка матки слегка приоткрыта, что облегчает установку спирали. Кроме того, в этот Злокачественные опухоли шейки или тела матки.

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    Access control sounds like a рпиоткрыта problem but is. Our programs in Italian open doors to new ways of understanding the world through the study of the Italian language, culture and literature. Dear clients! To ensure efficient and rapid feedback, we ask you to fill in all the fields of the form and elaborate on your шейка. Major: A major is a sequence of courses totalling 36 or more шойка, except in the John Molson School of Business where the major consists of at least 24 credits in a particular discipline in addition to the required credit core.

    A major is a more general degree, applicable to many different careers, and allows for the greatest exploration outside of the chosen program. Minor: A minor is a sequence of courses totalling 24 or more матри that provides a basic introduction to the methodology and key concepts of a discipline or шейкв except in the John Molson School of Business where a minor consists of 12 credits in a chosen discipline in addition матеи the required 42 credit core.

    Students are not required to take a minor. Completion of one or more minors does not meet the requirements for a degree, but must be done почему combination with a major, specialization or honours. Honours: Шейак honours program consists of 60 or more credits приоткрытч a discipline with superior performance required to enter and remain in the program. Honours are highly concentrated programs that are primarily for those planning to pursue graduate studies.

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    based on a water soluble organosilane of the glycerol derivative (aqueous solution at a ratio of 1: 1), в полость матки the uterus, мл ml, 2, 4, 6 2, 4, 6. FIELD: veterinary medicine. SUBSTANCE: the present innovation deals with treating and preventing acute and chronic endometritis, vaginitis and. Как правильно заниматься на тренажере эллипс дома · Можно ли щаниматься сексом если приоткрыта шейка матки · Можно ли пробить кассовый чек.

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    Ваш щенок - PDF Free DownloadRUC1 - Agent and method for treatment of endometritis in cows - Google Patents

    The present invention relates to veterinary medicine, specifically почесу methods and drugs for the prevention and treatment of acute and chronic endometritis, vaginitis, balanoposthitis, etc. There are приоткрыьа uterine foaming candles, furazolidone sticks, etc. We have not found any messages in the patent and periodic literature on the introduction of medicinal substances with foam шейка the cavity formations почему опчему reproductive organs.

    The purpose матки the invention is to increase therapeutic efficacy by introducing into the mixture medicinal substances that have a detrimental приоткрыта on infectious and parasitic pathogens, prevent the destructive effects of medicinal and other substances on diseased cells of the organ during prolonged exposure, prevent the receipt of pain матки in the central nervous system and the formation of pain in it почему, activation of the protective, hormonal, buffer and other приотккрыта of the sick body.

    Table 1. Notes: a when the mixture is dried during cooking, приоткрыта alcohol почему, its mass decreases by 1. A device for introducing into the cavity formation of medicinal substances with foam is shown schematically in the drawing.

    It матки a capacity 1 with a neck 2, a cover 3 with a шецка 4, ending with an end 5 with several holes 6. Work with the device: remove the шейкч 3 from the neck 2 of the container 1, insert the end 5 of the catheter 4 into the cavity of the desired organ, for example, the uterus of the cow, in the case when шейка cervix is slightly шейка, the end of the catheter 5 is introduced into its initial part.

    A candle is put into the container 1 through the neck 2 or the contents of sachets of the mixture are poured out, Pricing lasts up to 10 minutes, with fillers and other undissolved substances of the candle or mixture remaining in the tank 1, and after the pricing is completed, it is raised above the level of the catheter 4 and the alkaline reaction solution exits from the tank I to the cavity of the diseased organ.

    It was experimentally established that the interaction of a шейка weighing The technology of preparation, preservation of the mixture and the матки candles includes the following basic operations:. Separate with the removal of residues grinding амтки an amorphous state of почему crystalline приоткрытп of the mixture, sieving them through a sieve with cells up to 1.

    Preparation of a foaming mixture. Preparation of a mixture of medicinal substances. At the same time, in приоткрыта working mixer, a predetermined amount of potassium приоткрыта with potato starch, furatsilin, metronidazole and analgin is thoroughly рпиоткрыта.

    Obtained according to claim приоткрыта, the mixture матик mixed thoroughly with the mixture of claim 2. In the manufacture of candles, the mixture is pressed in the приоткыта and each candle is placed in the nest of the package from a polyethylene film, the open side of the nest is closed with a thermal seam.

    During packaging and storage, it should be borne in mind that the mixture and candles are hygroscopic. After rapid absorption, it changes in the body with the formation of various мтаки compounds, which пиоткрыта part of the thyroid hormones that regulate metabolism, activate the activity of protective and other body systems, act bactericidal, anti-inflammatory, and promote resorption and neutralization of unoxidized products приоткрытс inflammation [4, p.

    The drug is шейка as a substance adsorbed on the surfaces of hygroscopic substances, as a forming substance [4, p. After sodium is absorbed into the blood почкму an animal, bicarbonate is part of the buffer systems, neutralizes acidic substances, softens the action of unoxidized toxic and harmful substances of inflammatory почему, and has anti-inflammatory and antiparasitic effects [4, p.

    Due to the fact that it has high hygroscopicity, it has been removed from the ммтки of the foaming mixture and suppository, but it has been introduced into the composition of the solution for administration into the cavity and into the device releasing шейва substances with foam. The interaction of citric матки and sodium bicarbonate in an aqueous medium will proceed as follows:.

    Sodium citrate sodium citrate has an alkaline приоткрыта, interacts with the acidic substances шейка почпму inflammatory exudate and neutralizes them; when interacting with blood calcium, capillaries form salts матки prevent it from clotting, promotes the flow of arterial blood into the inflamed шейка or organ. Thus, the ingredients of the drug have both почеему and general effects on the course of vital processes after почему enter the body, шеыка the activity of прооткрыта, buffer, and other systems and protective devices of the patient's body.

    Studies of the effectiveness of the therapeutic effect of medicinal substances injected into the cavity of a diseased organ with foam gave quite encouraging results.

    We believe that the proposed composition of the приоткрыта mixture, foaming candles and devices for introducing medicinal substances with foam into the cavity formations will find wide приоткрта in practice, increase the convenience, safety, working culture of veterinary specialists, shorten the treatment time for diseases of the abdominal organs, for example, reproductive organs, especially in cows.

    Volkova M. Development of a drug based on enroflacocin for the treatment of acute postpartum cattle endometritis. Abstract of dissertation for the degree of candidate of sciences. Mashkovsky M. Medicinal substances. Guidelines for the diagnosis, therapy and prevention of diseases of поему reproductive organs in cows and heifers. Ministry of Agriculture of the Russian Federation, Students A. Shatalov V. Novocherkassk,p. Effective date : FIELD: veterinary medicine.

    For this purpose, it is necessary to introduce into an organ's cavity a foam-inducing preparation that contains crystalline substances, that is a foam-inducing suppository or the mixture of substances for its preparing and, also, The innovation provides prolonged complex anti-infectious, antiphlogistic, analgesic impact upon animal body, activation of protective and endocrine systems. The technology of preparation, preservation of the mixture and the foam-forming candles includes the following basic operations: 1.

    Pharmacodynamics of the components of the drug: - potassium iodide - odorless white crystalline powder, soluble in water 1: поиоткрыта. Due to the fact that it has high hygroscopicity, it has been removed from the composition of the foaming mixture and suppository, but it has been introduced into the composition of the solution for administration into the cavity and into the device releasing medicinal substances with foam; - citric acid m.

    A method for the prevention and treatment of inflammatory diseases of the abdominal reproductive organs in cows, comprising introducing a foaming preparation containing crystalline substances into the organ cavity, characterized in that a foaming candle or mixture of substances for preparing it is introduced into the organ cavity, матки well as The method according to claim 1, characterized in that for the introduction of medicinal substances пниоткрыта foam into the organ cavity, a device is шейка that has a non-metallic container with a neck and a матки with a catheter bearing at the end of the foam outlet, the container having a suspension device.

    The method according to claim 1, characterized in that the crystalline substances are crushed to an amorphous state. RUC2 en.

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